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Taking more than the recommended dose can increase side effects

Certain conditions may blunt or impede therapeutic response to methylcobalamin therapy

Thyroid hormone conversion may be affected by caloric restriction

Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified

Glob Chall 7:2200213 Li ZJ, Cho CH (2012) Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery

Sikiric, P., Seiwerth, S., Grabarevic, Z., Petek, M., Rucman, R., Turkovic, B., & Brkic, T